The terms disease, disorder, medical condition are often used interchangeably. There is no agreed-upon universal distinction between these terms, though some people do make distinctions in particular contexts.
Medical usage sometimes distinguishes a disease, which has a known specific cause or causes (called its etiology), from a syndrome, which is a collection of signs or symptoms that occur together. However, many conditions have been identified, yet continue to be referred to as "syndromes." Furthermore, numerous conditions of unknown etiology are referred to as "diseases" in many contexts. Refractory diseases do not respond to therapy by overcoming the resistance to drugs.
Illness, although often used to mean disease, can also refer to a person's perception of their health, regardless of whether they in fact have a disease. A person without any disease may feel unhealthy and simply have the perception of having a disease. Another person may feel healthy with similar perceptions of perfectly good health. The individual's perception of good health may even persist with the medical diagnosis of having a disease; for example, such as dangerously high blood pressure, which may lead to a fatal heart attack or stroke.
Pathology is the study of diseases. The subject of systematic classification of diseases is referred to as nosology. Its cause is referred as its etiology. The broader body of knowledge about human diseases and their treatments is medicine. Many similar (and a few of the same) conditions or processes can affect non-human animals (wild or domestic). The study of diseases affecting animals is veterinary medicine.
Disease can be thought of as the presence of pathology, which can occur with or without subjective feelings of being unwell or social recognition of that state. Illness as the subjective state of "unwellness" can occur independently of, or in conjunction with, disease or sickness (with sickness the social classification of someone deemed diseased, which can also occur independently of the presence or absence of disease or illness (c.f. subjective medical conditions). Thus, someone with undetected high blood pressure who feels to be of good health would be diseased, but not ill or sick. Someone with a diagnosis of late-stage cancer would be diseased, probably feeling quite ill, and recognized by others as sick. A person incarcerated in a totalitarian psychiatric hospital for political purposes could arguably be then said to not be diseased, nor ill, but only classified as sick by the rulers of a society with which the person did not agree. Having had a bad day after a night of excess drinking, one might feel ill, but one would not be diseased, nor is it likely that a boss could be convinced of the sickness.
Sunday, December 23, 2007
Causes nof diseases
Many different factors intrinsic or extrinsic to a person (or plant or animal) can cause disease. Examples of intrinsic factors are genetic defects or nutritional deficiencies. An environmental exposure, such as second-hand smoke is an example of an extrinsic factor. Many diseases result from a combination of intrinsic and extrinsic factors. For many diseases, no cause or set of causes has been identified.
There are many different factors that can cause disease. These can be broadly categorized into the following categories such as social, psychological, chemical, and biological. Some factors may fall into more than one category. Biochemical causes of disease can be considered as a spectrum where at one extreme disease is caused entirely by genetic factors (e.g. CAG repeats in the Huntingtin gene that causes Huntington's Disease) and at the other extreme is caused entirely by environmental factors. Environmental factors include toxic chemicals (e.g. acetaldehyde in cigarette smoke and dioxins released from the breakdown of Agent Orange) and infectious agents (e.g. smallpox virus and poliovirus). In between these extremes genes (e.g. NOD2/CARD15) and environmental factors (e.g. Gut microbiota) interact to cause disease, as seen for example in the inflammatory bowel disease Crohn's Disease .
Absence of the genetic or environmental factors in this case results in disease not being manifest. Koch's postulates can be used to determine whether a disease is caused by an infectious agent.
To determine whether a disease is caused by genetic factors, researchers study the pattern inheritance of the disease in families. This provides qualitative information about the disease (how it is inherited). A classic example of this method of research is inheritance of hemophilia in the British Royal Family. More recently this research has been used to identify the Apoliprotein E (ApoE) gene as a susceptibility gene for Alzheimer's Disease, though some forms of this gene - ApoE2 - are associated with a lower susceptibility. To determine to what extent a disease is caused by genetic factors (quantitative information), twin studies are used. Monozygotic twins are genetically identical and likely share a similar environment whereas dizygotic twins are genetically similar and likely share a similar environment. Thus by comparing the incidence of disease (termed concordance rate) in monozygotic twins with the incidence of disease in dizygotic twins, the extent to which genes contribute to disease can be determined. Candidate disease genes can be identified using a number of methods. One is to look for mutants of a model organism (e.g. the organisms Mus musculus,Drosophila melanogaster, Caenhorhabditis elegans,Brachydanio rerio and Xenopus tropicalis) that have a similar phenotype to the disease being studied. Another approach is to look for segregation of genes or genetic markers (e.g. single nucleotide polymorphism or expressed sequence tag
A large number of SNPs spaced throughout the genome have been identified recently in a large project called the HapMap project[1][2]). The usefulness of the HapMap project and SNP typing and their relevance to society was covered in the 27 October 2005 issue of the leading international science journal Nature (journal).
A large number of genes have been identified that contribute to human disease. These are available from the US National Library of Medicine, which has an impressive range of biological science resources available for free online. Amongst these resources is Online Mendelian Inheritance in Man - OMIM that provides a very, very comprehensive list of all known human gene mutations associated with, and likely contributing to, disease. Each article at OMIM is regularly updated to include the latest scientific research. Additionally, each article provides a detailed history of the research on a given disease gene, with links to the research articles. This resource is highly valuable and is used by the world's top science researchers. WHO defines heatlh as a, State of physically,mentally,socially,economically and spiritually well being not merely the absence of disease or infirmity.
There are many different factors that can cause disease. These can be broadly categorized into the following categories such as social, psychological, chemical, and biological. Some factors may fall into more than one category. Biochemical causes of disease can be considered as a spectrum where at one extreme disease is caused entirely by genetic factors (e.g. CAG repeats in the Huntingtin gene that causes Huntington's Disease) and at the other extreme is caused entirely by environmental factors. Environmental factors include toxic chemicals (e.g. acetaldehyde in cigarette smoke and dioxins released from the breakdown of Agent Orange) and infectious agents (e.g. smallpox virus and poliovirus). In between these extremes genes (e.g. NOD2/CARD15) and environmental factors (e.g. Gut microbiota) interact to cause disease, as seen for example in the inflammatory bowel disease Crohn's Disease .
Absence of the genetic or environmental factors in this case results in disease not being manifest. Koch's postulates can be used to determine whether a disease is caused by an infectious agent.
To determine whether a disease is caused by genetic factors, researchers study the pattern inheritance of the disease in families. This provides qualitative information about the disease (how it is inherited). A classic example of this method of research is inheritance of hemophilia in the British Royal Family. More recently this research has been used to identify the Apoliprotein E (ApoE) gene as a susceptibility gene for Alzheimer's Disease, though some forms of this gene - ApoE2 - are associated with a lower susceptibility. To determine to what extent a disease is caused by genetic factors (quantitative information), twin studies are used. Monozygotic twins are genetically identical and likely share a similar environment whereas dizygotic twins are genetically similar and likely share a similar environment. Thus by comparing the incidence of disease (termed concordance rate) in monozygotic twins with the incidence of disease in dizygotic twins, the extent to which genes contribute to disease can be determined. Candidate disease genes can be identified using a number of methods. One is to look for mutants of a model organism (e.g. the organisms Mus musculus,Drosophila melanogaster, Caenhorhabditis elegans,Brachydanio rerio and Xenopus tropicalis) that have a similar phenotype to the disease being studied. Another approach is to look for segregation of genes or genetic markers (e.g. single nucleotide polymorphism or expressed sequence tag
A large number of SNPs spaced throughout the genome have been identified recently in a large project called the HapMap project[1][2]). The usefulness of the HapMap project and SNP typing and their relevance to society was covered in the 27 October 2005 issue of the leading international science journal Nature (journal).
A large number of genes have been identified that contribute to human disease. These are available from the US National Library of Medicine, which has an impressive range of biological science resources available for free online. Amongst these resources is Online Mendelian Inheritance in Man - OMIM that provides a very, very comprehensive list of all known human gene mutations associated with, and likely contributing to, disease. Each article at OMIM is regularly updated to include the latest scientific research. Additionally, each article provides a detailed history of the research on a given disease gene, with links to the research articles. This resource is highly valuable and is used by the world's top science researchers. WHO defines heatlh as a, State of physically,mentally,socially,economically and spiritually well being not merely the absence of disease or infirmity.
Disease in human body
A disease is an abnormal condition of an organism that impairs bodily functions.[citation needed] In human beings, "disease" is often used more broadly to refer to any condition that causes discomfort, dysfunction, distress, social problems, and/or death to the person afflicted, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories.[citation needed]
While many diseases are biological processes with observable alterations of organ function or structure, others primarily involve alterations of behavior.
Classifying a condition as a disease is a social act of valuation, and may change the social status of the person with the condition (the patient). Some conditions (known as culture-bound syndromes) are only recognized as diseases within a particular culture. Sometimes the categorization of a condition as a disease is controversial within the culture.
While many diseases are biological processes with observable alterations of organ function or structure, others primarily involve alterations of behavior.
Classifying a condition as a disease is a social act of valuation, and may change the social status of the person with the condition (the patient). Some conditions (known as culture-bound syndromes) are only recognized as diseases within a particular culture. Sometimes the categorization of a condition as a disease is controversial within the culture.
Specialities
In addition to general dentistry, there are 9 recognized dental specialties in the US, Canada, and Australia. To become a specialist requires one to train in a residency or advanced graduate training program. Once residency is completed, the doctor is granted a certificate of specialty training. Many specialty programs have optional or required advanced degrees such as (MD/MBBS specific to Maxillofacial Surgery), MS, or PhD.
Dental Public Health (study of dental epidemiology and social health policies),
Endodontics (root canal therapy and study of diseases of the dental pulp),
Oral and Maxillofacial Pathology (study, diagnosis, and sometimes the treatment of oral and maxillofacial related diseases),
Oral and Maxillofacial Radiology (study and radiologic interpretation of oral and maxillofacial diseases),
Oral and Maxillofacial Surgery (extractions, facial surgery and implants),
Orthodontics and Dentofacial Orthopaedics (straightening of teeth and modification of midface and mandibular growth),
Pediatric Dentistry (i.e. dentistry for children, formerly known as "pedodontics"),
Periodontics (treatment of the periodontium, however most periodontists place implants),
Prosthodontics (dentures, bridges and the restoration of implants. Some prosthodontists further their training in "oral and maxillofacial prosthodontics--a discipline concerned with the replacement of missing facial structures--such as ears, eyes, nose, etc.)
Specialists in these fields are designated registrable (U.S. "Board Eligible") and warrant exclusive titles such as orthodontist, oral and maxillofacial surgeon, endodontist, pediatric dentist, periodontist, or prosthodontist upon satisfying certain local (U.S. "Board Certified"), (Australia/NZ: "FRACDS"), or (Canada: "FRCD(C)") registry requirements.
Two other post-graduate formal advanced education programs: General Practice Residency (advanced clinical and didactic training with intense hospital experience) and Advanced Education in General Dentistry (advanced training in clinical dentistry) recognized by the ADA do not lead to specialization.
Special category: Oral Biology - Research in Dental and Craniofacial Biology
Other dental education exists where no post-graduate formal university training is required: cosmetic dentistry, dental implant, temporo-mandibular joint therapy. These usually require the attendance of one or more continuing education courses that typically last for one to several days. There are restrictions on allowing these dentists to call themselves specialists in these fields. The specialist titles are registrable titles and controlled by the local dental licensing bodies.
Forensic odontology consists of the gathering and use of dental evidence in law. This may be performed by any dentist with experience or training in this field. The function of the forensic dentist is primarily documentation and verification of identity.
Geriatric dentistry or geriodontics is the delivery of dental care to older adults involving the diagnosis, prevention, and treatment of problems associated with normal ageing and age-related diseases as part of an interdisciplinary team with other health care professionals.
Veterinary dentistry, a speciality of veterinary medicine, is the field of dentistry applied to the care of animals [2][3].
Dental Public Health (study of dental epidemiology and social health policies),
Endodontics (root canal therapy and study of diseases of the dental pulp),
Oral and Maxillofacial Pathology (study, diagnosis, and sometimes the treatment of oral and maxillofacial related diseases),
Oral and Maxillofacial Radiology (study and radiologic interpretation of oral and maxillofacial diseases),
Oral and Maxillofacial Surgery (extractions, facial surgery and implants),
Orthodontics and Dentofacial Orthopaedics (straightening of teeth and modification of midface and mandibular growth),
Pediatric Dentistry (i.e. dentistry for children, formerly known as "pedodontics"),
Periodontics (treatment of the periodontium, however most periodontists place implants),
Prosthodontics (dentures, bridges and the restoration of implants. Some prosthodontists further their training in "oral and maxillofacial prosthodontics--a discipline concerned with the replacement of missing facial structures--such as ears, eyes, nose, etc.)
Specialists in these fields are designated registrable (U.S. "Board Eligible") and warrant exclusive titles such as orthodontist, oral and maxillofacial surgeon, endodontist, pediatric dentist, periodontist, or prosthodontist upon satisfying certain local (U.S. "Board Certified"), (Australia/NZ: "FRACDS"), or (Canada: "FRCD(C)") registry requirements.
Two other post-graduate formal advanced education programs: General Practice Residency (advanced clinical and didactic training with intense hospital experience) and Advanced Education in General Dentistry (advanced training in clinical dentistry) recognized by the ADA do not lead to specialization.
Special category: Oral Biology - Research in Dental and Craniofacial Biology
Other dental education exists where no post-graduate formal university training is required: cosmetic dentistry, dental implant, temporo-mandibular joint therapy. These usually require the attendance of one or more continuing education courses that typically last for one to several days. There are restrictions on allowing these dentists to call themselves specialists in these fields. The specialist titles are registrable titles and controlled by the local dental licensing bodies.
Forensic odontology consists of the gathering and use of dental evidence in law. This may be performed by any dentist with experience or training in this field. The function of the forensic dentist is primarily documentation and verification of identity.
Geriatric dentistry or geriodontics is the delivery of dental care to older adults involving the diagnosis, prevention, and treatment of problems associated with normal ageing and age-related diseases as part of an interdisciplinary team with other health care professionals.
Veterinary dentistry, a speciality of veterinary medicine, is the field of dentistry applied to the care of animals [2][3].
General dentistry
Dentists can (and often do) further their training in one or more speciality areas (such as surgery, endodontics, orthodontics, etc.) Hence, there can be a great deal of variation between the level of skill in different disciplines from dentist to dentist, however all dentists must achieve a certain degree of skill in various disciplines in order to graduate from dental school and earn licensure. General practitioners, unlike specialists, have the luxury of choosing which services they will provide and which they will refer to specialists. It is important to note that most general practitioners perform restorative, prosthetic, routine endodontic therapy, routine periodontal therapy, and simple exodontia, as well as performing examinations. Others are comfortable treating more complex cases, as well as placing implants and extracting third molars...among many other procedures frequently referred to specialists. Contrary to popular belief, most dentists do not regularly clean teeth, and instead delegate this task to their support staff (e.g. dental hygienists).
Dentistry
Dentistry is the "evaluation, diagnosis, prevention and/or treatment (nonsurgical, surgical or related procedures) of diseases, disorders and/or conditions of the oral cavity, maxillofacial area and/or the adjacent and associated structures and their impact on the human body".[1] Those in the practice of dentistry are known as dentists. Other people aiding in oral health service include dental assistants, dental hygienists, dental technicians, and dental therapists.
A dentist is a healthcare professional qualified to practice dentistry after graduating with a degree of either Doctor of Dental Surgery (DDS), Doctor of Dental Medicine (DMD), Bachelor of Dentistry (BDent), Bachelor of Dental Science (BDSc), or Bachelor of Dental Surgery/Chirurgiae (BDS) or (BChD) or equivalent. In most western countries, to become a qualified dentist one must usually complete at least 4 years of postgraduate study[citation needed]. Generally, 2 years of clinical experience working with patients in an educational setting are required.[citation needed
A dentist is a healthcare professional qualified to practice dentistry after graduating with a degree of either Doctor of Dental Surgery (DDS), Doctor of Dental Medicine (DMD), Bachelor of Dentistry (BDent), Bachelor of Dental Science (BDSc), or Bachelor of Dental Surgery/Chirurgiae (BDS) or (BChD) or equivalent. In most western countries, to become a qualified dentist one must usually complete at least 4 years of postgraduate study[citation needed]. Generally, 2 years of clinical experience working with patients in an educational setting are required.[citation needed
Health systems in Asia
Israel,[37] South Korea, Seychelles and Taiwan have universal health care. Thailand[38] plans to.[39] Health care in India is guaranteed to "improve" for all under the constitution, although the reality does not live up to the vague wording of the article. In Sri Lanka, drugs are provided by a government owned drug manufacturer called the State Pharmaceuticals Corporation of Sri Lanka. In the Philippines, the Department of Health (Philippines) organises public health for the country, and was established at the initiative of the American governors, before independence. Saudi Arabia has a publicly funded health system, although its levels are lower than the regional average.
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